Wnt and Extraocular Muscle Sparing in Amyotrophic Lateral Sclerosis

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Unchanged Neurotrophic Factors and Their Receptors Correlate With Sparing in Extraocular Muscles in Amyotrophic Lateral Sclerosis.

Purpose To investigate the impact of amyotrophic lateral sclerosis (ALS) on the extraocular muscles (EOMs) by examining the distribution of neurotrophic factors (NTFs) and their receptors in EOMs and limb muscles from ALS transgenic mice. Methods Muscle samples collected from transgenic mice overexpressing human superoxide dismutase type 1 mutations (SOD1G93A, the most widely used mouse model...

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A Muscle Perspective on the Pathophysiology of Amyotrophic Lateral Sclerosis - Differences between extraocular and limb muscles

..................................................................................................................... VI ABBREVIATIONS ....................................................................................................... VIII LIST OF ORIGINAL PAPERS ..................................................................................... IX

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ژورنال

عنوان ژورنال: Investigative Opthalmology & Visual Science

سال: 2014

ISSN: 1552-5783

DOI: 10.1167/iovs.14-14886